Evaluation of a New Automatic CPAP Algorithm in the Treatment of Obstructive Sleep Apnea Syndrome Authors: W. Galetke,

Background: Automatic Continuous Positive Airway Pressure (automatic CPAP, APAP) is an effective treatment option for Obstructive Sleep Apnea Syndrome (OSAS). The differentiation of obstructive and central respiratory events is crucial in adjusting the optimal pressure in this treatment mode. In this pilot study we evaluated a new automatic CPAP algorithm in OSAS patients. Methods: Fourteen (14) patients with newly diagnosed Obstructive Sleep Apnea Syndrome were enrolled. After a diagnostic polysomnography, patients were treated for one night with a new APAP device equipped with an algorithm based on flow, snoring, relative minute volume and the obstructive pressure peak signal. Results: The total apnea/hypopnea index (AHI) was 30.0 ± 21.4/hr at baseline and 3.7 ± 5.3/hr with APAP (p < 0.005). Both obstructive AHI (22.7 ± 20.5/hr at baseline, 1.5 ± 3.5/hr with APAP, p < 0.005) and central AHI (7.3 ± 4.9/hr and 2.2 ± 2.5/hr, respectively, p < 0.01) and the arousal index (25.4 ± 18.1/hr and 5.1 ± 3.8/hr, respectively, p < 0.005) were reduced significantly with the new algorithm. Conclusions: The new algorithm of an automatic CPAP device is effective in the treatment of Obstructive Sleep Apnea Syndrome.